Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA
Small interfering RNAs (siRNAs) are revolutionizing the treatment of liver-associated indications.Yet, robust delivery to extrahepatic tissues remains a challenge.Conjugating lipids (e.g., docosanoic acid [DCA]) to siRNA supports extrahepatic delivery, but tissue accumulation remains lower Office Technology than that achieved in liver by approved s